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Public release date: 9-May-2012

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Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press

Reduction of excess brain activity improves memory in amnestic mild cognitive impairment

Research published by Cell Press in the May 10th issue of the journal Neuron, describes a potential new therapeutic approach for improving memory and modifying disease progression in patients with amnestic mild cognitive impairment. The study finds that excess brain activity may be doing more harm than good in some conditions that cause mild cognitive decline and memory impairment.

Elevated activity in specific parts of the hippocampus, a brain region involved in memory, is often seen in disorders associated with an increased risk for Alzheimers disease. Amnestic mild cognitive impairment (aMCI), where memory is worse than would be expected for a persons age, is one such disorder. In the case of early aMCI, it has been suggested that the increased hippocampal activation may serve a beneficial function by recruiting additional neural resources to compensate for those that are lost, explains senior study author, Dr. Michela Gallagher, from Johns Hopkins University. However, animal studies have raised the alternative view that this excess activation may be contributing to memory impairment.

Dr. Gallagher and colleagues tested how a reduction of hippocampal activity would impact human patients with aMCI. The researchers used a low dose of a drug used clinically to treat epilepsy, for the purpose of reducing hippocampal activity in subjects with aMCI to levels that were similar to activity levels in healthy, age-matched subjects in a control group. The researchers found that treatment with the drug improved performance on a memory task. These findings point to the therapeutic potential of reducing excess activation in the hippocampus in aMCI.

The results also have broader significance as elevated activity in the hippocampus is also observed in other conditions that are thought to precede Alzheimers disease, and may be one of the underlying mechanisms of neurodegeneration. Apart from a direct role in memory impairment, there is concern that elevated activity in vulnerable neural networks could be causing additional damage and, possibly, widespread disease-related degeneration that underlies cognitive decline and the conversion to Alzheimers disease, concludes Dr. Gallagher. Therefore, reducing the elevated activity in the hippocampus may help to restore memory and protect the brain.

By Fredrik Dahl

VIENNA |
Wed May 9, 2012 11:12am EDT

Classic fitness advice says kids need an hour of vigorous activity every day. In theory, that makes sense. In real life, it can be tough figuring out whether your childs gotten 5, 10 or 200 minutes of activity in a day. When theyre in school, youre not there to see what theyre doing. And even when theyre at home playing in the backyard or jumping around in the basement, theyre not actually in constant motion kids play and even most kids games (from kickball to freeze tag to soccer) involve lots of starts and stops.

But a cheap piece of technology could help. Plenty of kids will wear a pedometer. And a new studyof 1,613 kids ages 6 to 19 says that by checking the number on the screen, you can estimate their activity level. Researchers from Canadas Childrens Hospital of Eastern Ontario Research Institute determined that kids who get 12,000 steps a day are hitting the 60-minute goal. Step counts are something that children and teens can easily monitor themselves and use to work toward personal health goals, says lead author Rachel Colley, PhD

You could spend $25 to $99 (no, thats not a mis-print!) for a special kids pedometer. But dont do it. Pedometers get dropped, lost, left in pants pockets and run through the washer and dryer. A cheaper model makes more sense; youll find pedometers that cost as little as $5 in local discount stores.

But dont just hand one to your kid or teen. Get one for yourself (experts recommend that adults work up to 10,000 steps daily, roughly 5 miles) and for other family members and start a friendly competition. The more you move, the more your child will, too. In one fascinating French study of 286 families, researchers found that parents who logged the most steps had kids who did, too. Or help your child log her steps on fun Web sites like PE Centrals Log It.

Plenty of kids in the Philadelphia area already wearing pedometers. In West Philadelphia, a program called Dance for Health brought University of Pennsylvania nursing program professors and students out to Sayre High School for weekly dance classes with kids and adults ages 5 to 91. Participants wore pedometers and found that they got twice as many steps on dance days.

Growing activity fees limit student participation

Parents are convinced and research shows that students who participate in extra curricular activities do better in school and in life.

That’s why seeing school boards increase fees for students to play sports, act, debate and sing is so frustrating to parents who are strapped to pay the fees.

Granted school districts are short of funds, primarily because the state legislature won’t provide the dollars necessary to keep up with inflation. At the same time, voters are reluctant to approve extra tax levies for schools.

School boards are caught in the middle as they face million-dollar budget deficits  and view these activities as “extra” and not basic to a child’s education.

As a result, parents have to pay more, run fund-raisers and even take second jobs so their children can play sports and play an instrument in the marching band.

Never was this scenario more dramatic than in the Lakeville school district facing a $15.8 million budget deficit. In Lakeville, it costs a fee of $600 to play hockey, $440 to play basketball and $300 to participate in competitive cheerleading.

By pleading to booster clubs, doubling fees and cutting school services the district was able to save varsity gymnastics, track and golf.

Weary parents are being tapped out, in addition to paying fees. They are paying school activity fees and booster club dues, to say nothing about the costs of equipment for their sons and daughters.

The sad fact in Lakeville and around the state is kids whose parents can’t afford the fees are not playing, particularly at the junior varsity level.

The very kids that are being cut, however, may be the ones who need sports the most.  Athletic and activity directors will tell you they know many students who would have dropped out of high school if it hadn’t been for sports.

At Lakeville’s neighboring schools, the fees are lower and participation is steady.

Farmington, for example, charges a $300 fee regardless of number of sports played.

What’s the answer? Some will say that schools have to have outside funding to keep varsity athletics.

The Osseo school district four years ago opted to cut out junior high school sports so a full program of varsity sports, some seventh through 12th grades, could be offered.  As a result, the fee to play a sport is $180, and it’s $90 for students qualifying for reduced lunch price and no cost for students qualifying for free lunch.

At Anoka high school, it costs $320 to play hockey, $290 for football, $280 for track and $240 for the fall marching band. These fees are possible because the voters in Anoka-Hennepin passed the last extra levy, and booster clubs continue to provide the uniforms.

Like the districts above, Forest Lake has been forced to raise its fee rates, but not to the extremes seen here. For example, the fee to play varsity hockey in Forest Lake is $298 while football players pay a $263 fee. Participants in basketball and drumline all pay a $315 fee.

Forest Lake’s fee structure also takes into account family budget considerations.

A family will pay no more than $1150 a year in fee for students who are involved in activities in grades 7-12. The family rate is very helpful to families with multiple sons and daughters involved in sports and other activities such as speech and debate.

In Lakeville, an organization called the “Stray Cats,” made up of parents of graduates, helps parents pay the fees. In 2011-2012, “Stray Cats” assisted 50 families whose students played 14 different sports for 22 different teams.

Parents need to lobby their legislators and their school boards to provide funds for these co-curricular programs, and they need to approve extra tax levy questions, otherwise fewer kids will get the benefits of participating in these character-building activities. — Don Heinzman

NEW YORK, NY, May 09, 2012 (MARKETWIRE via COMTEX) –
In recent months the Biotech Industry has become a hotbed of Merger
and Acquisition (M&A) activity and speculation. As large
pharmaceuticals face major patent expirations in 2012 they have
looked to biotech companies to provide new streams of revenue. Given
the limited amount of quality companies, the ones with quality drugs
and proven technologies stand to gain the most. Five Star Equities
examines the outlook for companies in the Biotech Industry and
provides equity research on Complete Genomics, Inc.

/quotes/zigman/1318953/quotes/nls/gnom GNOM
-3.41%


and Neostem Inc.

/quotes/zigman/1507799/quotes/nls/nbs NBS
-0.08%



.

Access to the full company reports can be found at:

www.FiveStarEquities.com/GNOM

www.FiveStarEquities.com/NBS

The U.S. patent system will see a major change for the first time in
over 60 years. The America Invents Act (AIA) will see the U.S. patent
system transform from a “first to invent” to a “first to file”
system. The majority of countries around the world have already
adopted the “first to file” system. The AIA will help benefit biotech
companies “by enhancing patent quality and the efficiency,
objectivity, predictability and transparency of the U.S. patent
system,” BIO President and CEO Jim Greenwood stated in a press
release. “Small biotechnology companies rely heavily on their patents
to attract investment,” and “they will benefit from the improvements
to our nation’s patent system made by this legislation,” added
Greenwood.

Five Star Equities releases regular market updates on the Biotech
Industry so investors can stay ahead of the crowd and make the best
investment decisions to maximize their returns. Take a few minutes to
register with us free at
www.FiveStarEquities.com and get exclusive
access to our numerous stock reports and industry newsletters.

Complete Genomics is the whole human genome sequencing company that
has developed and commercialized an innovative DNA sequencing
platform. Complete Genomics ended the first quarter 2012 with $63.1
million in cash, cash equivalents and short-term investments and $0.5
million in restricted cash. The company’s backlog as of March 31,
2012 was approximately 5,700 genomes, including about 1,000 genomes
booked in the first quarter, representing an aggregate revenue
potential of approximately $27 million.

NeoStem is an international biopharmaceutical company with global
research and development capabilities. In the United States the
Company is a provider of adult stem cell collection, processing and
storage services enabling healthy individuals to donate and store
their stem cells for personal therapeutic use. Similar to the banking
of cord blood, pre-donating cells at a younger age helps to ensure a
supply of one’s own stem cells should they be needed for future
medical treatment.

Five Star Equities provides Market Research focused on equities that
offer growth opportunities, value, and strong potential return. We
strive to provide the most up-to-date market activities. We
constantly create research reports and newsletters for our members.
Five Star Equities has not been compensated by any of the
above-mentioned companies. We act as an independent research portal
and are aware that all investment entails inherent risks. Please view
the full disclaimer at:

www.FiveStarEquities.com/disclaimer

Contact:
Five Star Equities
Email Contact

SOURCE: Five Star Equities

http://www2.marketwire.com/mw/emailprcntct?id=22E37D3A7F106FF0

Copyright 2012 Marketwire, Inc., All rights reserved.

/quotes/zigman/1318953/quotes/nls/gnom

Add to portfolio

GNOM

Complete Genomics Inc.

US

: U.S.: Nasdaq


$
1.98

-0.07
-3.41%

Volume: 1.19M
May 11, 2012 4:00p

P/E RatioN/A
Dividend YieldN/A

Market Cap$70.32 million
Rev. per Employee$64,388

/quotes/zigman/1507799/quotes/nls/nbs

Add to portfolio

NBS

Neostem Inc.

US

: U.S.: NYSE Amex


$
0.37

-0.0003
-0.08%

Volume: 719,970
May 11, 2012 4:00p

P/E RatioN/A
Dividend YieldN/A

Market Cap$48.01 million
Rev. per Employee$93,789

Financial Glossary

Words used in this article:





NEW YORK (Reuters Health) – A small safety trial suggests a pacemaker-like device implanted into the brains of Alzheimers patients may stimulate beneficial brain activity in some.

The results do not signal the device could someday cure the disease, but that it may restore some measure of activity in areas of the brain whose decline is linked to Alzheimers symptoms like memory loss, depression and agitation.

Jurmaine Dowe detaches his digital pedometer and inserts it into the docking station, and its not long before a flurry of colourful graphics pop up and saturate the computer screen.

Within moments, the 11-year-old will be on a globetrotting journey within a virtual world that will transport him to such varied locales as Blackfoot Crossing, the Empire State Building, Mount Everest, and the moon.

But before the Grade 5 student at Torontos Blacksmith Public School can navigate through the digital domain, he first must rack up steps through physical activity to power his online play.

Jurmaine is among 250 kids across Canada taking part in a pilot project aimed at offering youngsters some added incentive to get moving.

Concerned Childrens Advertisers has launched what is being billed as the first-ever online game to use kids daily activity as its sole power source.

The projects aim is to determine whether gaming can be used as a motivator to change sedentary behaviour, and, in turn, increase physical activity levels among kids.

In addition to other communities within Ontario including Mississauga, Paris, Orillia and Rama, the pilot is also in place in Moncton, Regina and Whitehorse.

Children are outfitted with digital pedometers known as Fitbits that track and upload their daily steps to an online game called GOGOYU. When online, they create and customize their own avatars.

But for parents concerned about kids spending countless hours glued to screens, they neednt worry: the game has strict time limits, and offers ample educational value to its users.

Participants must reach a minimum daily physical activity goal of 8,000 steps, and a built-in timer limits game play to 20 minutes a day.

As they navigate through the game, they can earn energy boosters known as karats, learn nutritional information as well as facts about the different locales which are woven throughout the various challenges.

The pilots first week involves students wearing the Fitbit daily without interaction with GOGOYU. An online survey is also conducted to assess their sports involvement and levels of activity, said CCA school liaison Susan Houston.

The students then have four weeks interacting with the game. During the projects final phase, youngsters wear the Fitbit for one more week to see if they are continuing to keep up with their steps.

CCA president Bev Deeth said research they conducted with kids revealed that youngsters recognize the importance of leading a healthy, active life. However, that knowledge alone wasnt necessarily enough to spur them to take action or make a change.

The information was shared with ad agency Crispin Porter amp; Bogusky, which developed the idea of a game powered by real-life activity.

With one in four kids in this country being overweight or obese, this is taking a very creative new direction approach to an issue thats very problematic, Deeth said. We felt that we were reaching kids in more of a relevant and meaningful and motivating way.

Deeth said the game is designed to help kids get their 60 minutes of recommended moderate to vigorous physical activity a day.

According to the 2011 report card from Active Healthy Kids Canada, only nine per cent of boys and four per cent of girls are meeting those targets.

Recent research from the Childrens Hospital of Eastern Ontario Research Institute suggests kids should accumulate about 12,000 steps daily to maintain healthy physical activity levels. The step-count figure includes the recommended 60 minutes of daily physical activity.

Soccer sessions at school for Jurmaine and fellow classmates Nathaniel Sinke and Shirley Tran, both 10, have helped in their efforts to ramp up their step counts.

I was psyched because it was kind of fun hearing about the game, seeing my character and everything, and seeing how many steps I could get a day… and trying to beat my highest step count, said Jurmaine.

Shirley has racked up as many as 21,000 steps in a day and does whatever she can to increase her pedometer clicks.

When were doing squats, I always add marches to it to get more steps.

Justin Dockery, a fifth-grade teacher at Blacksmith, said while the main focus has been on physical activity, they have also had informal conversations with the students about the places they are visiting in the game.

Not all of the kids have been keen to participate. Andrew Wood, who teaches a split Grade 4/ 5 class at Blacksmith, admits a few of his students havent worn the Fitbit at all.

Youre not going to get everybody. But the point is: `How many can you get? he said.

Some kids arent going to be on board. But the point is to get more on board than otherwise, added Dockery.

The pilot is slated to wrap up next month, and results will be reviewed by researchers at the University of Toronto.

Michelle Brownrigg, director of physical activity and equity at U of T, has examined a fair bit of research looking at screen time and its correlation to physical inactivity. She said the pilot project is an interesting, new contribution to exploring the relationship between screen time and being physically active.

Everything that we can look at that can figure out how we can engage kids, engage families, that will put them into a situation of building physical activity into daily life is all a good contribution.

12:41am Misc.-Patrol Check Officer initiated activity at Heritage Park, 201 Eighth St, Taft. Checks OK.

9:40am Vehicle Check Incident location was 400 Center St, Taft. Advised.

11:31am Assist other Departments Officer initiated activity at 308 Tyler St, Ford City. Outside assist.

1:51pm Vehicle Code-All Other Violations Officer initiated activity at 100 E. Kern St, Taft. Moving violation cite.

2:04pm Unlicensed Driver Officer initiated activity at 400 Finley Dr, Taft. Arrest made. Cite/released.

2:57pm Miscellaneous Disturbance Incident location was 810 N. Sixth St, Lincoln Jr High School, Taft. Report taken.

3:31pm Warrant Arrest-Other Agency KCSO reported. Incident location was 100 Wood St, South Taft. Arrest made.

4:13pm Assist other Departments Incident location was 100 Center St, Taft. Assisted.

4:21pm Assist other Departments Incident location was 512 Washington Av #B, Taft. Assisted.

5:35pm Taft City Ordinances Officer initiated activity at Skate Park, 500 Cascade Pl, Taft. Moving Violation Cite.

5:40pm Vandalism-Less than $1,000 Incident location was 800 San Emidio St, Taft. Unfounded.

8:47pm Burglary-Auto San Emidio, reported 460 PC to vehicle. Report taken.

9:42pm Misc.-Patrol Check Officer initiated activity at Skate Park, 500 Cascade Pl, Taft. Checks OK.

2:27am Assist other Departments Officer initiated activity at Polk St/Elm St, Ford City. Outside assist.

Jimenez, Mayolo Ortiz Misdemeanor warrant

By Allen Sykora
Of Kitco News
http://www.kitco.com/

Editor’s note: Catch the Latest Happenings with Kitco Video News!

(Kitco News) -Kinross Gold Corp. (TSX: K, NYSE: KGC) says infrastructure development is on schedule and mining activity has accelerated at the Tasiast mine in the African nation of Mauritania, while a feasibility study at the Dvoinoye project in Russia is been completed and the board has approved full construction spending.

The company’s gold output declined year-on-year in the first quarter, but Kinross looks for higher levels in each of the three remaining quarters of 2012.

Kinross provided an update on its growth projects and mining activity during a conference call with analysts Wednesday morning in conjunction with the late-Tuesday release of first-quarter earnings.

Kinross reported net earnings of $105.7 million, or 9 cents a share, down from $250.1 million, or 22 cents a share, in the first quarter of 2011. Earnings were impacted by a re-measurement of deferred tax liabilities and a $110.3 million non-cash item that was the result of an increase in Ghana’s corporate tax rate.

Excluding special items, adjusted earnings were $203.1 million, or 18 cents a share, an increase from $175.3 million, or 15 cents, in the year-ago period.

Revenue rose 11% from the year-ago period to $1.04 billion due to higher gold prices. The production cost of sales was $742 per gold-equivalent ounce, up from $545 a year ago as a result of increased processing of lower grades and higher power, labor and contractor costs. The margin was $902 an ounce, a 15% decline.

Kinross reported production of 604,247 gold-equivalent ounces in the first quarter, excluding a 10% non-controlling interest at Chirano in Ghana, down 6% from a year ago. The company attributed the drop to a scheduled decline in grade at Kupol in Russia, a scheduled increase in processing of lower-grade stockpile ore at La Coipa in Chile and below-plan production at Tasiast.

“We are maintaining our production and cost guidance for 2012, as production for each of the remaining quarters of this year is expected to exceed the first quarter as per our annual plan,” said Tye Burt, president and chief executive officer. The company expects output of 2.6 million to 2.8 million gold-equivalent ounces for the full year at a cost of $670 to $715 an ounce.

North American production was down to 149,092 ounces in the first quarter from 153,020 in the year ago period and also fell from the fourth quarter. Kinross linked this to lower mill feed grades at Fort Knox and a slightly lower gold release from the heap leach due to winter conditions. North American output should rise in the second half of the year due to accelerated heap processing and improved mill processing grades at Fort Knox, Kinross said.

Ouput at Kupol in Russia fell to 126,970 ounces from 205,675 in the year-ago period. Kinross reported reduced gold and silver head grades as operations moved out of depleted high-grade areas.

WFC Wells Fargo amp; Co. – Financial stocks were among the weakest performers as trading got underway this morning, spurring bearish activity in options on the largest banks. Shares in Wells Fargo are down 1.3% at $32.73 as of midday in New York, having surrendered a total of 5.4% since reaching a more than three-year high of $34.59 on April 2nd. Weekly put buying on San Francisco, California-based Wells Fargo amp; Co. suggests some traders anticipate the stock may continue to sell off through the end of this week. The May 11 ’12 $32 strike put saw the most action, with more than 2,600 of the contracts purchased for an average premium of $0.16 apiece this morning. Put buyers may profit at expiration if shares in WFC decline another 2.7% to breach the average breakeven point on the downside at $31.84.

MS Morgan Stanley – Investors in Morgan Stanley are feeling more pain today, with shares in the name down 0.50% at $15.76 in early afternoon trading on the heels of a more than 25.0% move lower since the end of March. Options traders looking to benefit from further potential weakness in the shares snapped up more than 3,200 puts at the May 11 ’12 $15 strike for an average premium of $0.13 apiece. Traders long the weekly $15 puts on the financial services firm stand ready to profit in the event that shares in Morgan Stanley drop another 5.6% to trade below the average breakeven price of $14.87. Shares in MS last traded south of $14.87 back in December 2011.

ODP Office Depot, Inc. – A large ratio call spread initiated in office supplies retailer, Office Depot, Inc., this morning may result in a sizable payoff should the price of the underlying rally sharply during the next five months. Shares in ODP are down 1.3% this afternoon to stand at $2.33 as of 12:35 pm ET. The stock has dropped nearly 40.0% since the end of March and is down 60.0% since this time last year, but one strategist is prepared to benefit from a substantial move to the upside. It looks like the trader purchased 5,750 calls at the Oct. $3.0 strike for an average premium of $0.225 each and sold 11,500 calls up at the Oct. $4.0 strike at a premium of $0.05 apiece. The ratio spread cost $0.125 per contract and yields profits in the event that ODP’s shares surge 34.1% to surpass the effective breakeven price of $3.125. Maximum potential profits of $ are available on the trade should shares in Office Depot jump 71.7% to settle at $4.00 at October expiration.

CPWM Cost Plus, Inc. – Shares in the home goods retailer are up 21.65% today at $21.88 after Bed Bath amp; Beyond, Inc. agreed to purchase the Oakland, California-based company for around $495 million, or $22.00 a share. One trader who appears to have purchased some call options on Cost Plus last week is now holding contracts that have quadrupled in value. It looks like the strategist picked up 75 calls at the May $17.5 strike last Friday at a premium of $1.10 each when shares in Cost Plus were hovering around $17.75. Premium required to purchase these contracts today has risen to $4.50 as of 11:50 am in New York.